Transfusion-associated circulatory overload (TACO) – a breathtaking syndrome.

Transfusion-associated circulatory overload (TACO) is the leading cause of transfusion related morbidity and mortality. The underlying mechanism for onset of TACO is unknown. The current proposal aims through a translational approach to understand the mechanisms involved in the onset of TACO and establish a basis to develop preventive and therapeutic strategies for this life threatening syndrome.