Jaar: 2010
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Amelioration of sickle cell disease and ß-thalassemia: reactivation of g-globin gene expression.
The red blood cell or erythrocyte is the most abundant cell type in the blood circulation. This cell type is highly specialized to carry out its main function: the transport of oxygen from the lungs to the other parts of…
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Dynamic fibrin clot formation: a haemostatic process involving multiple blood components and a possible surrogate end point for transfusion.
In this project a flow assay has been developed and validated, incorporating the functions of blood platelets, coagulation and fibrinolysis factors and the contribution of red and white blood cells to the process of thrombus formation and fibrin clot formation.…
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Neutrophil killing: a reappraisal of granulocyte transfusions for patients with fungal infections.
Invasive fungal infections are characterized by high rates of mortality and represent an increasing problem in medicine. This is due to intensified use of immunosuppressive treatments and neutropenia but also occurs in the context of inherited diseases related to the…
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Role of the microtubule network in the generation and expansion of the first hematopoietic stem cells.
Every day, blood stem cells in the bone marrow produce billions of new blood cells essential for life. Defects in blood stem cells lead to blood-related disorders and various cancers (e.g. anemia, leukemia). The only long-term treatment is to transplant…
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T cell modulation of hematopoiesis.
Bone marrow is not only the organ in which new blood cells are generated, but also an immunologically active site where immune responses against pathogens can be initiated. Recognition of a virus inside the bone marrow leads, just like in…
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T cell modulation of hematopoiesis.
Bone marrow is not only the organ in which new blood cells are generated, but also an immunologically active site where immune responses against pathogens can be initiated. Recognition of a virus inside the bone marrow leads, just like in…
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The molecular basis of leukocyte transendothelial migration: from intracellular GEFs to intercellular gaps.
Nowadays we know that the blood vessel is much more than a blood transport duct. White blood cells move through the blood vessel wall, and the vessel wall by means of the endothelial cell actively supports in this process. It…
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The molecular basis of leukocyte transendothelial migration: from intracellular GEFs to intercellular gaps.
Nowadays we know that the blood vessel is much more than a blood transport duct. White blood cells move through the blood vessel wall, and the vessel wall by means of the endothelial cell actively supports in this process. It…