Jaar: 2012
-
Control of erythropoiesis by iron dependent expression of protein isoforms.
The number of erythrocytes in peripheral blood has to be controlled between narrow limits. Too few erythrocytes results in anemia and carries the risk of tissue damage by ischemia, whereas too many erythrocytes enhances the risk for stroke. Therefore, the…
-
Dissection of immunomodulatory mechanisms affecting adoptive transfer of peripheral blood derived-tumor reactive T cells in combination with low-dose IFN-alpha as treatment for advanced melanoma.
In our ongoing clinical trial we treat patients that suffer from metastatic melanoma with T cells that recognize and attack the tumor. These tumor-reactive T cells are derived from peripheral blood cells that were stimulated with the patient’s’ own tumor…
-
From in vitro erythropoiesis to transfusion.
Despite the many donors who donate blood every year, it is sometimes difficult for some repeatedly transfused patients to find compatible blood. This is especially true for patients (eg sickle cell disease) who have been immunized against various foreign antigens…
-
From in vitro erythropoiesis to transfusion.
Despite the many donors who donate blood every year, it is sometimes difficult for some repeatedly transfused patients to find compatible blood. This is especially true for patients (eg sickle cell disease) who have been immunized against various foreign antigens…
-
Gatekeepers of the vasculature; regulation of exocytosis by syntaxin binding proteins.
The endothelium forms a highly dynamic physical barrier that separates blood from the underlying tissues. It is critically involved in self-healing mechanisms of the blood vessel that prevent infection and excessive blood loss upon vascular injury. In the event of…
-
Neutrophil cytotoxic granules in microbial infection and cancer.
Of all white blood cells the (neutrophilic) granulocytes are most abundant in our blood. Granulocytes play a crucial part in the defense against bacteria and fungal infections. This is illustrated by the notion that a decrease in numbers of granulocytes…
-
Understanding clinically significant allo- and auto-immunity towards blood cells.
The results of this work contribute to the understanding of antibody-mediated allo- and autoimmunity towards blood cells. As such they also contribute to the development of new diagnostic assays to predict the severity of alloantibody-derived blood diseases like hemolytic disease…