Jaar: 2015
-
Development of RNA-targeted therapies for bleeding disorders, especially von Willebrand disease.
Patients with von Willebrand disease (VWD) have a defect in the process of blood coagulation. Therefore, they develop bruises easily and it takes longer for a bleeding to stop. Patients develop VWD because of a defect in von Willebrand factor…
-
Functional dissection of C-reactive protein’s role in exacerbating cellular clearance.
In this project, we followed up previous work suggesting that inflammation, more particularly the acute phase response leading to elevated C-Reactive Protein (CRP) levels, can exacerbate symptoms in antibody mediated disorders when they target platelets causing thrombocytopenia’s. This can be…
-
Genetics and epigenetics in megakaryopoiesis: the role of GFI1B.
Inherited bleeding disorders caused by a paucity in properly functioning platelets have a negative impact on life quality and if not properly treated can be life threatening. A better understanding of the causes of bleeding disorders may eventually lead to…
-
Interaction between Choline Transporter-like Protein 2 and Von Willebrand Factor: Importance to Transfusion-related Acute Lung Injury and Beyond.
Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusion. In TRALI, blood transfusion can cause unwanted activation of the neutrophils circulating in the blood, with consequences for the cells that line the blood vessels of the lungs…
-
Interactions of hemostatic proteins with the vasculature: go with the flow?
Hemostasis is the biological process that prevents and stops bleeding. It is achieved by a delicate triadic interplay between the vessel wall, blood platelets and coagulation factors. It has become increasingly clear that blood flow is an integral part of…
-
Interactions of hemostatic proteins with the vasculature: go with the flow?
Hemostasis is the biological process that prevents and stops bleeding. It is achieved by a delicate triadic interplay between the vessel wall, blood platelets and coagulation factors. It has become increasingly clear that blood flow is an integral part of…
-
Plasmin to the rescue in thrompotic thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura (TTP) is a rare but devastating autoimmune disease. It is caused by antibodies that neutralize ADAMTS13. This enzyme prevents thrombosis of the microvasculature by continuously “trimming” the multimeric protein von Willebrand Factor (VWF). In its absence (as…
-
Towards a more effective and efficient use of intravenous immunoglobulin in children with immune thrombocytopenia.
In children, skin bleeding may be the first indication that the patient suffers from immune thrombocytopenia (ITP). In this autoimmune disease, the own immune system attacks proteins which are located on platelets. Subsequently, the platelets get damaged, resulting in a…