Jaar: 2017
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Dissecting the role of Neogenin; a novel receptor required for hematopoietic stem cell proliferation and engraftment.
Medical conditions like anemia, deficient immune system and different kinds of leukemia happen more often in elderly people. It was later found that different kinds of damage, which happen in these stem cells, are actually partially responsible for these diseases.…
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Modifying factor XI to promote hemostasis: a novel therapeutic approach to control bleeding?
Haemostasis is a tight balance between coagulation and bleeding. Disruption of this balance will either lead to over-coagulation (thrombosis) or under-coagulation (bleeding). The coagulation cascade is a protein network central to haemostasis that is involved in maintaining this tight balance.…
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Platelet subsets and priming: functional determinants in haemostasis and vascular protection.
Platelets are essential players in thrombosis and haemostasis. However, not all platelets are exact copies of each other, and distinct platelets in a subject can respond differently to the same inhibitors or activators. This results in the formation of different…
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The Ig-glycan code: a third level of memory controlling effector function of immunoglobulins in health and disease.
In this project we set out to understand why the human immune system reacts with a unique antibody signature to foreign blood cells with an enhanced inflammatory nature. The properties that are altered in these immune responses, are sugar structures…
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The role of heme oxygenase-1 in the development of graft versus host disease.
Allogeneic hematopoietic stem cell transplantation (HSCT) is often the only curative option for hematological malignancies such as acute myeloid leukemia (AML) and non-malignant blood disorders such as sickle cell disease. However, allogeneic HSCT is limited by acute graft- versus-host disease…
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Von Willebrand factor release from Weibel-Palade bodies: pulling the strings in vascular disease.
The endothelium is a thin layer of endothelial cells and forms the inner lining of our blood vessel, which separates blood from the underlying tissue. The vessel wall is equipped with a number of self-healing properties that prevent infection and…